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In vitro, modafinil has long been demonstrated to bind weakly but selectively to the dopamine transporter (Mignot et al 1994; Nishino et al 1998; Madras et al 2006) and, into a lesser extent, the norepinephrine transporter (Madras et al 2006). Wake-marketing concentrations of modafinil improved extracellular levels of monoamines, which include nore